CLINICAL TRIALS AND OBSERVATIONS Bone mineral density in adult survivors of childhood acute leukemia: impact of hematopoietic stem cell transplantation and other treatment modalities
نویسندگان
چکیده
1Department of Paediatric Onco-hematology, Hospital L’Archet II, Nice, France; 2Research Unit EA 3279 and Department of Public Health, Hôpital Nord, Marseille, France; 3Department of Paediatric Hematology, Children’s Hospital of La Timone, Marseille, France; 4Department of Paediatric Onco-hematology, Hospital Arnaud de Villeneuve, Montpellier, France; and 5Department of Paediatric Onco-Hematology, Children’s Hospital of Brabois, Vandoeuvre Les Nancy, France
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Bone loss following hematopoietic stem cell transplantation: a long-term follow-up
Transplantation-associated bone loss is a well-known phenomenon, however, effects of hematopoietic stem cell transplantation are insufficiently characterized. We conducted a prospective, unicentric, longterm follow-up in 280 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Bone mineral density (BMD) was measured before transplantation and then yearly for at least 4...
متن کاملNonmyeloablative allogeneic hematopoietic stem cell transplantation.
Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patient...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase
Reduced-intensity or nonmyeloablative stem cell transplantation (NST) is designed to induce host-versus-graft tolerance by engraftment of donor stem cells. The rationale behind NST is to induce optimal graft-versus-leukemia (GVL) effects for elimination of all malignant cells by donor alloreactive immunocompetent cells as an alternative to standard highdose myeloablative chemoradiotherapy. NST ...
متن کاملAllogeneic peripheral blood stem cell transplantation as an alternative to allogeneic bone marrow transplantation.
BMT, including 1) rapid hematopoietic engraftment, 2) less requirement for blood transfusion, antibiotic therapy and hospitalization days, and 3) avoidance of.risks and discomfort associated with general anesthesia for collecting hematopoietic stem cells (2). Taking these advantages into consideration, the use of PBSCwas applied for syngeneic and allogeneic transplantation in the early 1990' s....
متن کاملCLINICAL TRIALS AND OBSERVATIONS Acute mixed lineage leukemia in children: the experience of St Jude Children’s Research Hospital
To characterize the biology and optimal therapy of acute mixed-lineage leukemia in children, we reviewed the pathologic and clinical features, including response to therapy, of 35 patients with mixedlineage leukemia. The majority of cases (91%) had blasts cells that simultaneously expressed either T-lineage plus myeloid markers (T/myeloid, n 20) or B-lineage plus myeloid markers (B/myeloid, n 1...
متن کامل